OrangerV1, Main, Exploration, bibRecord, 001587

Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress

Identifieur interne : 001587 ( Main/Exploration ); précédent : 001586; suivant : 001588

Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress

Auteurs : Zong-Tsi Chen [Taïwan] ; Heuy-Ling Chu [Taïwan] ; Charng-Cherng Chyau [Taïwan] ; Chin-Chen Chu [Taïwan] ; Pin-Der Duh [Taïwan]

Source :

Food chemistry [ 0308-8146 ] ; 2012.

RBID : Pascal:12-0394264

Descripteurs français

Pascal (Inist)
- Orange, Citrus sinensis, Pelure, Stress oxydatif, Hespéridine.

English descriptors

KwdEn :
- Caspase 3 (genetics), Caspase 3 (metabolism), Chromatography, High Pressure Liquid, Citrus sinensis, Citrus sinensis (chemistry), Fruit (chemistry), Glutathione (metabolism), Hep G2 Cells, Hesperidin, Humans, Membrane Potential, Mitochondrial (drug effects), Orange, Oxidative Stress (drug effects), Oxidative stress, Peel, Plant Extracts (analysis), Plant Extracts (pharmacology), Protective Agents (analysis), Protective Agents (pharmacology).
MESH :
- chemical , analysis : Plant Extracts, Protective Agents.
- chemical , genetics : Caspase 3.
- chemical , metabolism : Caspase 3, Glutathione.
- chemistry : Citrus sinensis, Fruit.
- drug effects : Membrane Potential, Mitochondrial, Oxidative Stress.
- chemical , pharmacology : Plant Extracts, Protective Agents.
- Chromatography, High Pressure Liquid, Hep G2 Cells, Humans.

Abstract

Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress were investigated. According to HPLC-DAD and HPLC-MS/MS analysis, hesperidin (HD), hesperetin (HT), nobiletin (NT), and tangeretin (TT) were present in water extracts of sweet orange peel (WESP). The cytotoxic effect in 0.2 mM t-BHP-induced HepG2 cells was inhibited by WESP and their bioactive compounds. The protective effect of WESP and their bioactive compounds in 0.2 mM t-BHP-induced HepG2 cells may be associated with positive regulation of GSH levels and antioxidant enzymes, decrease in ROS formation and TBARS generation, increase in the mitochondria membrane potential and Bcl-2/Bax ratio, as well as decrease in caspase-3 activation. Overall, WESP displayed a significant cytoprotective effect against oxidative stress, which may be most likely because of the phenolics-related bioactive compounds in WESP, leading to maintenance of the normal redox status of cells.

Affiliations:

Taïwan

Le document en format XML

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<front><div type="abstract" xml:lang="en">Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress were investigated. According to HPLC-DAD and HPLC-MS/MS analysis, hesperidin (HD), hesperetin (HT), nobiletin (NT), and tangeretin (TT) were present in water extracts of sweet orange peel (WESP). The cytotoxic effect in 0.2 mM t-BHP-induced HepG2 cells was inhibited by WESP and their bioactive compounds. The protective effect of WESP and their bioactive compounds in 0.2 mM t-BHP-induced HepG2 cells may be associated with positive regulation of GSH levels and antioxidant enzymes, decrease in ROS formation and TBARS generation, increase in the mitochondria membrane potential and Bcl-2/Bax ratio, as well as decrease in caspase-3 activation. Overall, WESP displayed a significant cytoprotective effect against oxidative stress, which may be most likely because of the phenolics-related bioactive compounds in WESP, leading to maintenance of the normal redox status of cells.</div>
</front>
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Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress

Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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